Chiara Sanguinetti
Phd Student in Clinical Physiopathology - Academic Year 2018-2019
Curriculum: Cardiopulmonary
Research project: Characterization of gamma-glutamyltransferase protein as inducer of the expression of tissue factor in peripheral blood mononuclear cell (PBMC)s harvested from normal human donors. A new role for GGT in the pathogenesis of cardiovascular events?
Supervisor: Prof. Andrea Pedrinelli
Chiara Sanguinetti, graduated in Biology Applied to Biomedicine in 2018, is now attending the last year of PhD in Clinical Physiopathology. The aim of her study is to analyze the pro-coagulant and proinflammatory role of g-glutamyltransferase (GGT) as possible inductor of tissue factor expression, the main activator of coagulation cascade, through the engagement of toll-like receptor-4. Thus, this research wants to increase the little information now available about the association between circulating GGT and chronic inflammatory events associated with acute thrombotic phenomena.
Scientific Articles
- Scatena, C., et al., Dabrafenib and Trametinib prolong coagulation through the inhibition of tissue factor in BRAF. Cancer Cell Int, 2019. 19: p. 223.
- Neri, T., et al., Tiotropium inhibits proinflammatory microparticle generation by human bronchial and endothelial cells. Sci Rep, 2019. 9(1): p. 11631.
Contacts
- chiara.sanguinetti@phd.unipi.it